Membranous nephropathy (MN) is the predominant 
cause of nephrotic syndrome in adults.Furthermore, sirolimus has been 
reported to reduce proteinuria and decrease glomerular 
IgG deposition, as evidenced by immunofluorescence 
studies [16].Sirolimus (rapamycin), widely used to prevent allograft 
rejection in organ transplantation [13], exerts immuno-
suppressive effects through inhibition of the mamma-
lian target of rapamycin (mTOR)--a serine/threonine 
kinase critical for T-cell activation and proliferation 
[14].