Abstract:
Purpose: We aimed to detect the ameliorating effects of Moringa leaves extract (MLE) against Methotrexate (MTX) induced hippocampus damage.The immunohistochemical study focusing on P53 immunoreactivity showed that the contrasting findings in P53 expression between the control and MLE-treated groups suggest that MLE may modulate the expression of this tumor suppressor gene in the hippocampus.Rats were divided into to equal five groups; Group I: served as a control group, Group II: received MLE orally (300 mg/kg b w) twice a week for four weeks, Group III: injected intraperitoneal with MTX (0.5mg/kg b w) twice a week for four weeks, Group IV: rats received MTX and MLE at the same timeline for four weeks with the same dose and route of administration as mentioned previously, Group V: received MTX firstly followed by MLE for four weeks with the same dose and route of administration as mentioned previously.