Abortion
PGE2 and PGF2?[79,80] The drug is now least 
preferred because of its serious toxicity such as 
cardiovascular collapse, chances of anaphylactic shock 
and pulmonary hypertension.[73,74]
PGs or its derivatives in current practice are:
Dinoprostone: It is a synthetic derivative of PGE2 which 
is administered vaginally for inducing abortion in the 
second trimester of pregnancy and for ripening of the 
cervix for induction of labour at full term.These prostaglandins are used for first and 
second-trimester abortion and appear to soften the 
cervix, before abortion, by increasing proteoglycan 
content and changing the collagen characteristics.Its plasma 
half-life is 2.5-5 min.