Down syndrome is associated with immunosuppressive diseases, including skin conditions such as alopecia, eczema and psoriasis.Ethical Consideration (Human Subject Protections) The guarantees in place in our study are that there will be no emotional or physical harm, and from an ethical standpoint, we will not mention the names of patients and their private information.The second goal of our study is to determine the prevalence of Down syndrome and the relationship of Down syndrome to psoriasis Hypothesis : - Our hypothesis is to prove that Down syndrome is linked to psoriasis and is more common than alopecia and eczema There is a relationship between Down syndrome and psoriasis due to weak immunity- Data Collections A questionnaire was prepared with the required questions and was sent to the general public on social networking sites and centers.Descriptive statistics were performed using frequency tables and bar plot to describe categorical data such as age, gender, nationality, and skin diseases.The objectives of the study and the most prominent results of our research are that there are more females than males, and there are more people between the ages of 10 and 20 than other ages, and biological treatments had a positive effect on 17 people out of 18 Research question: Is there a relationship between Down syndrome and psoriasis?Hypothesis : - Our hypothesis is to prove that Down syndrome is linked to psoriasis and is more common than alopecia and eczema There is a relationship between Down syndrome and psoriasis due to weak immunity- Purpose: The purpose of this study is to find the relationship between Down syndrome and psoriasis.We obtained (111 ) from the responses to the questionnaire Many people who do not have relatives with Down syndrome were excluded, and the number became (68).Patients suffering from this syndrome are known to produce excessive amounts of endorphins.