Noroviruses are members of the Caliciviridae family.The advantages of working with this system are that the capsids do not contain RNA, and thus are non-infective, and that studies have shown that these particles are similar in size, shape, appearance and antigenicity to the infective virus particles (Jiang et al., 1992).The genome is 7.7 Kb, and contains three open reading frames: VP1 (the major capsid protein), VP2 (the minor capsid protein), and a non-structural polyprotein (Jiang et al., 1993).Noroviruses (NoV) have been genetically classified into five genogroups; GII and GI are the genogroups primarily associated with human diseases, although NoV GIV has occasionally been implicated in outbreaks (Zheng et al., 2006).Straub et al. (2007) described a three-dimensional in vitro system using human embryonic intestinal epithelial cell line INT-407; however, difficulty in adapting the system to other laboratories and the length of time required for the assay has precluded its widespread adoption.