An irregular pattern of substance use that results in impairment, tolerance, and withdrawal is known as substance misuse.Methylphenidate is a somewhat effective off-label usage for cancer-related tiredness, refractory depression in older individuals, apathy in Alzheimer disease patients, and cognitive enhancement (e.g., memory improvement).These children frequently worry about performing poorly academically and may feel pressured to improve it due to the challenging adjustments brought about by various integrated curricula.Fatigue, insomnia, and sadness are among withdrawal symptoms, and excessive dosages can cause fatal convulsions or cardiovascular failure.Recent worldwide data indicates that 1.3 million teens reported taking the popular brand names for methylphenidate, Ritalin or Adderall, over the previous 12 months.13.5% of Israeli medical students who participated in a 2015 survey acknowledged using methylphenidate in the previous 12 months, 10.0% of students said they had ever received an ADHD diagnosis.Just 2% of second- and fourth-year medical students at one South African institution reported having an ADHD diagnosis, whereas 13.1% (33/251) reported using drugs for non-medical purposes in the year prior.Peer pressure, stress, economic insecurity, and a lack of parental involvement were additional stressors.[7,8,9,10,11] School of Medicine Graduation Project Manuscript Hallucinations, nervousness, dry mouth, and visual problems are just a few of the many adverse effects that students using methylphenidate may encounter.[3,4,5,6] Research indicates that pharmaceutical addiction may be particularly common among medical students.