The spectacular progress in the field of stem cells research represents great scope of stem cells regenerative therapeutics.For advancement of translational application of stem cells, there is a need of clinical trials, which needs funding rejoinder from both public and private organizations.Except few countries, the ongoing financial and ethical hindrance on ESCs application in regenerative medicine have more chance for funding agencies to distribute funding for the least risky projects on UCSCs, BMSCs, and TSPSCs from biopsies.There is high optimism for use of BMSCs, TSPSCs, and iPSCs for treatment of various diseases to overcome the contradictions associated with ESCs.Inductions of pluripotency phenotypes in terminally differentiated adult cells have better therapeutic future than ESCs, due to least ethical constraints with adult cells.