It mainly presents with inflammation of the rectal and sigmoid colon about 40 to 50%.The ileocecal area 40% of Crohn's cases involve the ileal and ileo colonic area.The main areas affected, as we talked about is the rectal sigmoid area and this is termed proctitis.So IBD typically involves involve the colon.Now the two types of IBD are ulcerative colitis and Crohn's disease.Some people who have Crohn's can have skip lesions in the colon, the large intestine.In Crohn's disease, the main area affected is the cecum and the ileum.The second most common area affecting Crohn's is the small intestine.When talking about ulcerative colitis.