For practical reasons, initial testing is usually done shortly after a clinical event, followed by confirmatory testing at least 12 weeks later.5 Some nuances should be discussed though.At the time of an acute thromboembolic event, acute phase reactants such as C reactive protein, factor VIII, and fibrinogen might be markedly increased, altering coagulation test results (either increasing or decreasing times) and making it particularly important that lupus anticoagulant testing is repeated once the patient is stable.In addition, acute events have long been known to trigger the appearance of transient anticardiolipin antibodies,75 especially of low titer.