Zinc oxide has a widespread use in cosmetic
products.It is necessary to focus on making products with a
controlled particle size and minimal agglomeration. Besides its authorized use as a cosmetic
colorant with the Color Index No.CI 77947 (Council
Directive 76/768/EHS in Annex IV), zinc oxide is
applied as bulking agent and skin protecting UV
absorber [1].In early 2009, the Therapeutic Goods
Administration (TGA) conducted an updated review
of the scientific literature in relation to the use of
nanoparticulate zinc oxide and titanium dioxide in
sunscreens.Moreover
Sharma [5] proved in his study that zinc oxide NPs
cause statistically significant DNA damage at
concentrations of 5 and 0.8ug/ml in human
epidermal cells.Using nanosized particles in cosmetics
generates products with improved texture, more
vibrant color, and greater skin penetration [3].Therefore, it is essential to
understand the fate of these agglomerates upon to
ascertain whether subsequent toxicological effects
are attributable to the nanoparticle physical
properties or are a function of their chemical
composition.These nanoparticles (NPs) with
dimensions less than 100nm allow tailored product
formulations to meet the specific demands of the
consumer.Although zinc oxide is considered to
be non-toxic substance as it is practically insoluble
in water, there are incomplete data on its purity and
physico-chemical specifications of zinc oxide.In this study we wanted to contribute to the
awareness of the properties and behavior of oilbased dispersion with the contents of zinc oxide.The potential for zinc oxide NPs in
sunscreens to cause adverse effects depends
primarily upon the ability of the NPs to reach viable
skin cells.It is necessary to continue monitoring the
emerging scientific literature to ensure appropriate
action in case unacceptable risks are identified [6].There
is a lack of reliable data on the percutaneous
absorption of micronised zinc oxide [4].