Summary— This study investigated the effects of daily administration of three grams of tryptophan in conjunction with a high carbohydrate, low fat, low protein diet on chronic maxillofacial pain, experimental pain thresholds, and anxiety and depression In a double-blind study, 30 chronic pain patients were randomly assigned to a tryptophan or placebo group At the initial appointment and four weeks later the patients subjective ratings of their pain we were recorded , electrical tooth pulp stimulation was used to measure pain thresholds, and psychological tests of depression and anxiety were administered
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The group did not differ in anxiety and depression—for all subjects there was lowered depression and anxiety over the 4 weeks of study