Pharmacodynamics
They selectively inhibit serotonin transporter (SERT) -> inhibit serotonin reuptake & enhance serotonergic neurotransmission.Abrupt withdrawal -> headache, agitation, flu-like symptoms, abnormal sleep pattern (EXCEPT fluoxetine due to its long t1/2)
.Repeated administration leads to downregulation & desensitization of these auto receptors with reuptake inhibition -> enhanced serotonergic neurotransmission.Obsessive compulsive disorders (OCD)
.3
Pain associated with diabetic neuropathy and premenstrual syndrome.Adverse effects
Sexud douc
impstunee ??.8
Premature ejaculation (dapoxetine)
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