The traditional lobule is the most common description of a lobule, and you've probably heard of it. It's made up of hexagonal hepatocyte plates that are stacked on top of one another.In humans, connective tissue surrounds the portal canals, although the interlobular quantity is quite little.A periportal zone (Space of Mall) exists between the connective tissue of the portal canals and the hepatocytes, where lymph is generated.As hepatocytes expand towards the perimeter, they form strips, like the spokes of a cartwheel.These portal canals are made up of portal triads that are surrounded by loose stromal connective tissue.