The synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5?Based on the affinity score (GlideScore = -5.7 kcal.mol- 1
) and the proposed binding mode, 
Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic 
assays.-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect 
against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting 
EC50 = 0.1731 mg.mL- 1 and EC50 = 0.3243 mg.mL- 1
, respectively.-(hydrox ymethyl)-[2,2?