Acinetobacter resistance to antibiotics More than 25 years ago, it was found that acinetobacter bacteria had begun to become resistant to some antibiotics, including: aminopenicillin, first and second generation cephalosporin, aminoglycosides, cephamycin, chloramphenicol, and tetracycline.This has raised concerns from an epidemiological standpoint due to the importance of this group of antibiotics, which are often considered a last resort.The term Extensively drug-resistant A. baumannii (XDRAB) is used to distinguish bacterial isolates resistant to all antibiotics except polymyxin and tigecycline.The carbapenemase enzyme can be detected With a simple examination, as shown in the following image, by cultivating bacteria sensitive to carbapenems around a disk containing one of the carbapenems, and then cultivating the bacteria in which the enzyme is to be detected.The emergence of high levels of multi-resistant A. bumannii bacteria has made it a priority health issue and is considered a serious threat to healthcare facilities, public health and the elderly.