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needs to be continuously explored.Conclusions and Perspective As an important component of the cell, mitochondria contain genetic material, produce energy, and participate in a wide variety of metabolic activities in the cell.Here, we mainly analyzed the relationship between the heart and arterial-related CVDs, and mitochondrial dysfunction.4.

needs to be continuously explored.
4. Conclusions and Perspective
As an important component of the cell, mitochondria contain genetic material, produce
energy, and participate in a wide variety of metabolic activities in the cell. It can be seen
that if the mitochondrial dysfunction occurs, the normal replication of mtDNA, energy pro-
duction, and other functions will be affected, which may cause diseases. Here, we mainly
analyzed the relationship between the heart and arterial-related CVDs, and mitochondrial
dysfunction. Mitochondrial dysfunction in cardiomyocytes, vascular smooth muscle cells,
and endothelial cells causes a wide variety of CVDs; and has attracted more and more
scientists. With the deepening of CVDs pathogenesis related studies, we summarized the
mitochondrial dysfunction causing CVDs into four important characteristics, including
mtDNA mutations, impaired mitophagy, decreased OXPHOS, and mitochondrial-derived
ROS increase. In multiple animal and human models, many relevant intervention experi-
ments have been designed according to mitochondrial dysfunction, constantly exploring
more effective CVDs related therapeutic strategies. According to the four important char-
acteristics of mitochondrial dysfunction, the related treatment strategies of CVDs were
sorted out. Exploring the significance, advantages, and current limitations of different
mitochondrial targeted therapy strategies can provide more ideas and options for the treat-
ment of different CVDs. Although each of these strategies for ameliorating mitochondrial
dysfunction has its own characteristics, combination therapy may be more effective. It is
well known that CVDs are quite complex, and their pathological mechanisms are even more
complex and diverse. On the basis of continuously deepening the pathological mechanisms,
mitochondrial targets can be found more accurately. In the case of harmless to human
body, mitochondrial targeted therapy for CVDs may improve the efficiency and safety of
treatment, and contribute to the development of human health.
Author Contributions: Conceptualization, J.L. and Y.L. (Yongzhi Li); investig