لخّصلي

Early-life stress has been linked to changes in telomere length, which serves as an indicator of accumulated stress and aging, as well as a potential risk factor for psychiatric conditions.The observed relationships between adult telomere length, adolescent insulin resistance, and elevated pGLP-1 levels may signify an adaptive compensatory mechanism following exposure to early-life stress.We utilized regression modeling to assess the associations between adult telomere length and adolescent fasting pGLP-1 or insulin resistance, while controlling for sex, weight, and age.Furthermore, telomere length was positively correlated with pGLP-1 levels (p = .0009) and inversely associated with insulin sensitivity (p < .0001) across both sexes, independent of rearing group.Prior research has indicated elevated levels of plasma glucagon-like peptide 1 (pGLP-1) alongside insulin resistance in this context.It appears that insulin resistance may elevate pGLP-1 levels during adolescence, potentially safeguarding telomere length in VFD offspring as they mature.The maternal variable foraging demand (VFD) model in nonhuman primates is a recognized early-life stress paradigm that leads to anxiety and depressive-like behaviors in offspring.Methods involved measuring adult leukocyte telomere length in VFD-reared (12 males, 13 females) and non-VFD-reared (9 males, 26 females) bonnet macaques.

Early-life stress has been linked to changes in telomere length, which serves as an indicator of accumulated stress and aging, as well as a potential risk factor for psychiatric conditions. The maternal variable foraging demand (VFD) model in nonhuman primates is a recognized early-life stress paradigm that leads to anxiety and depressive-like behaviors in offspring. Prior research has indicated elevated levels of plasma glucagon-like peptide 1 (pGLP-1) alongside insulin resistance in this context. Our study aimed to explore the relationship between VFD rearing, adult telomere length, and these neuroendocrine markers. Methods involved measuring adult leukocyte telomere length in VFD-reared (12 males, 13 females) and non-VFD-reared (9 males, 26 females) bonnet macaques. We utilized regression modeling to assess the associations between adult telomere length and adolescent fasting pGLP-1 or insulin resistance, while controlling for sex, weight, and age. Results indicated that VFD subjects exhibited longer telomeres compared to their non-VFD counterparts (p = .017), with females showing longer telomeres than males (p = .0004). Furthermore, telomere length was positively correlated with pGLP-1 levels (p = .0009) and inversely associated with insulin sensitivity (p < .0001) across both sexes, independent of rearing group. In conclusion, contrary to expectations, VFD was linked to increased adult telomere length. It appears that insulin resistance may elevate pGLP-1 levels during adolescence, potentially safeguarding telomere length in VFD offspring as they mature. The observed relationships between adult telomere length, adolescent insulin resistance, and elevated pGLP-1 levels may signify an adaptive compensatory mechanism following exposure to early-life stress.