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Stimulation of excitatory neurons causes a movement of ions that results in a depolarization of the postsynaptic membrane.o These inhibitory postsynaptic potentials (IPSP) are generated by the following:

1. Stimulation of inhibitory neurons releases neurotransmitter molecules, such as ?-aminobutyric acid (GABA) or glycine, which bind to receptors on the postsynaptic cell membrane.o These excitatory postsynaptic potentials (EPSP) are generated by the following:
2. Stimulation of an excitatory neuron causes the release of neurotransmitter molecules, such as glutamate or acetylcholine, which bind to receptors on the postsynaptic cell membrane.Neurodegenerative diseases SYNAPTIC POTENTIALS B. Inhibitory pathways o Stimulation of inhibitory neurons causes movement of ions that results in a hyperpolarization of the postsynaptic membrane.

Stimulation of excitatory neurons causes a movement of ions
that results in a depolarization of the postsynaptic membrane.
• These excitatory postsynaptic potentials (EPSP) are generated
by the following:

1. Stimulation of an excitatory neuron causes the release of
   neurotransmitter molecules, such as glutamate or
   acetylcholine, which bind to receptors on the postsynaptic cell
   membrane. This causes a transient increase in the
   permeability of sodium (Na+) ions.


2. The influx of Na+ causes a weak depolarization, or EPSP, that
   moves the postsynaptic potential toward its firing threshold.


3. If the number of stimulated excitatory neurons increases,
   more excitatory neurotransmitter is released. This ultimately
   causes the EPSP depolarization of the postsynaptic cell to pass
   a threshold, thereby generating an all-or-none action
   potential.
   Neurodegenerative diseases
   SYNAPTIC POTENTIALS
   B. Inhibitory pathways
   • Stimulation of inhibitory neurons causes movement of ions
   that results in a hyperpolarization of the postsynaptic
   membrane.
   • These inhibitory postsynaptic potentials (IPSP) are generated
   by the following:


4. Stimulation of inhibitory neurons releases neurotransmitter
   molecules, such as γ-aminobutyric acid (GABA) or glycine,
   which bind to receptors on the postsynaptic cell membrane.
   This causes a transient increase in the permeability of specific
   ions, such as potassium (K+) and chloride (Cl−).


5. The influx of Cl− and efflux of K+ cause a weak
   hyperpolarization, or IPSP, that moves the postsynaptic
   potential away from its firing threshold. This diminishes the
   generation of action potentials.
   Neurodegenerative diseases