لخّصلي

Vascular Abnormalities: The integrity and health of blood vessels are important for normal hemostasis.Vascular abnormalities, such as vascular fragility or defects in the vessel wall, can lead to prolonged bleeding time [1].For example, nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, and antiplatelet agents can interfere with platelet aggregation or the coagulation cascade, resulting in prolonged bleeding time [2].Conditions like Ehlers-Danlos syndrome or hereditary hemorrhagic telangiectasia can affect blood vessel structure and function, contributing to bleeding disorders.These disorders are characterized by deficiencies or abnormalities in specific clotting factors or platelet function, leading to prolonged bleeding time [1].Extreme temperatures, particularly hypothermia, can impair platelet function and prolong bleeding time [3].

Vascular Abnormalities: The integrity and health of blood vessels are important for normal hemostasis. Vascular abnormalities, such as vascular fragility or defects in the vessel wall, can lead to prolonged bleeding time [1]. Conditions like Ehlers-Danlos syndrome or hereditary hemorrhagic telangiectasia can affect blood vessel structure and function, contributing to bleeding disorders.

Medications: Certain medications can affect platelet function and coagulation, leading to prolonged bleeding time. For example, nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, and antiplatelet agents can interfere with platelet aggregation or the coagulation cascade, resulting in prolonged bleeding time [2].

Inherited Bleeding Disorders: Inherited bleeding disorders, such as hemophilia or von Willebrand disease, can impact bleeding time. These disorders are characterized by deficiencies or abnormalities in specific clotting factors or platelet function, leading to prolonged bleeding time [1].

Acquired Bleeding Disorders: Various acquired conditions can affect bleeding time. Liver disease, kidney disease, disseminated intravascular coagulation (DIC), and certain types of cancer can disrupt the normal hemostatic process and prolong bleeding time [1].

Other Factors: Other factors that can influence bleeding time include hormonal imbalances, temperature, and age. Hormonal changes, such as those occurring during pregnancy or menopause, can affect platelet function and coagulation [1]. Extreme temperatures, particularly hypothermia, can impair platelet function and prolong bleeding time [3]. Additionally, advanced age can be associated with changes in platelet function and coagulation, potentially impacting bleeding time