: Clinical manifestations Zika virus (ZIKV) is a mosquito-borne flavivirus that gained global attention due to its association with neurological complications and adverse pregnancy outcomes.The clinical manifestations of Zika virus infection can range from asymptomatic cases to .mild flu-like symptoms, with some individuals developing more severe complications The most common symptoms of Zika virus infection include fever, rash, joint pain, and conjunctivitis.One notable complication is Guillain-Barre syndrome (GBS), a rare neurological disorder where the immune system attacks the nervous system, leading to muscle weakness and paralysis.Infection during pregnancy has been associated with congenital Zika syndrome (CZS), leading to severe birth defects such as microcephaly.