Synthetic progestogens (that is, progestins) used in contraception are more stable to first- pass metabolism, allowing lower doses when administered orally These agents include desogestrel [des-oh-JES-trel], dienogest [dye- EN-oh-jest), drospirenone [droe-SPY-re-none], levonorgestrel [lee- voe-nor-JES-trel], norethindrone [nor-ETH-in-drone], norethindrone acetate, norgestimate [nor-JES-tih-mate), and norgestrel [nor-JES- trel] Medroxyprogesterone [me-DROK-see-proe-JES-ter-one] ace- tate is an injectable contraceptive, and the oral form is a common progestin component of postmenopausal HT. Progestins are also used for the control of dysfunctional uterine bleeding, treatment of dysmenorrhea, and management of endometriosis and infertility