Hepatocellular carcinoma (HCC) is frequently associated with various comorbidities, which can complicate patient management and outcomes.Gender Differences: Male patients exhibited higher rates of hypertension and renal cysts, while female patients showed increased prevalence of chronic viral hepatitis C, hypersplenism, and coronary heart disease(Mu et al., 2020).Age Factor: The incidence of chronic diseases among comorbidities escalated with age, indicating a need for tailored management strategies for older patients(Mu et al., 2020).