Conclusion and perspectiv Identifying the process underlying replication origins and regulatory mechanisms has

 been one of a focal point in replication origin research.With the development of experimental technology, we are expected to add more
replication-related data, such as replication timing and epigenetic modification sites,
and provide online service for data analysis in the next update.On the one hand, with the explosive growth of origin-related

 datasets in cukaryotes, it has been a great impetus for researchers to explore the origin

characterization, firing and regulatory mechanisms of replication origins through

 computational analysis and prediction.Furthermore, DeOri is expected to play a crucial role
in experimental and computational studies of eukaryotic replication origins.