Attributal to small size and enhanced capability to penetrate into cells, NPs are awfully useful in a different biomedical 
applicances like antibacterial [27,28], antioxidant [27–29], anticancer [29–31], antifungal [32,33], antiviral [34,35], antiparasitic 
[36,37] anti-inflammatory activities [38,39] biosensing [40,41], bioimaging [41,42], diagnostics [43], drug delivery system [44,45], 
bioconjugation [46,47], hyperthermia [48], and biological therapies [49