What's fibromyalgia?FM is related to central sensitization processes and involves the loss of glial cells homeostasis FM patients frequently present other chronic pain syndromes, such as rheumatoid arthritis and endometriosis.Amitriptyline was also associated with improvement in pain fatigue, sleep, and quality of life and antidepressants, opioids, nonsteroidal anti-inflammatory drugs, sedatives, muscle relaxants, and antiepileptic drugsFibromyalgia is characterized by chronic widespread pain, fatigue, sleep disturbances and functional symptoms.o Fibromyalgia is the third most frequent musculoskeletal condition, and its prevalence increases with age.