CRUSH SYNDROME Crush syndrome, or traumatic rhabdomyolysis, refers to the clinical effects of injured muscle that, if left untreated, can lead to acute renal failure and shock. This condition is seen in individuals who have sustained a compression injury to significant muscle mass, most often to a thigh or calf. The muscular insult is a combination of direct muscle injury, muscle ischemia, and cell death with release of myoglobin