coronavirus disease (COVID-19) is the millennium's pandemic.Further, well-designed studies are needed to better elucidate the impact of COVID-19 on thyroid function and inform thyroid function testing and thyroid dysfunction management in COVID-19 patients.the cytokine storm associated with COVID-19 may influence thyroid function and/ or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 thyroid dysfunction is present in a significant percentage of patients with
COVID-19.The transmembrane protease serine 2 (TMPRSS2) and ACE2 form the primary molecular complex that SARS-CoV-2 utilizes to infect host cells.