The destruction occurred when ambition goes unchecked by moral constraints finds its most powerful expression in the play's two main characters.Macbeth is a courageous Scottish general who is not naturally inclined to commit evil deeds, yet he deeply desires power and advancement.Lady Macbeth, on the other hand, pursues her goals with greater determination, yet she one of Shakespeare's most forcefully drawn female characters, she spurs her husband mercilessly to kill Duncan and urges him to be strong in the murder's aftermath, but she is eventually driven to distraction by the effect of Macbeth's repeated bloodshed on her conscience.