In another study, Bolgen et al. performed in vivo
studies to examine nanofibrous drug delivery system
for intra-abdominal treatment.90 Both ornidazole (active
antibiotic against anaerobic intestinal bacteria) and bit-
eral antibiotic were embedded into biodegradable poly-
caprolactone by simply dropping antibiotic solution onto
the membranes. They reported that due to the combined
synergistic effect of membrane and the antibiotic, the
healing process becomes better and faster. Supaphol et al.
successfully prepared ultra-fine fiber mats of cellulose
acetate comprising of four model drugs, i.e., naproxen,
indomethacin, ibuprofen and sulindac by electrospinning.77
Mats of poly(vinyl alcohol) nanofibers with four different
types of non-steroidal anti-inflammatory drug with vari-
able water solubility; e.g., sodium salicylate, diclofenac
sodium, naproxen, and indomethacin were also developed
by them for transdermal drug delivery systems.91 Results
indicate that with an increasing molecular weight of a
drug, the rate and amount of drug release decreases. Also
the drug-loaded mats exhibited better release character-
istics as compared to solvent cast films due to a high
porosity of the electrospun nonwoven mats. Khil et al.
reported that electrospun polyurethane (PU) membranes
are useful as wound dressing material because it is able
to absorb wound exudates well, as it does not accumu-
late under the covering and does not lead to any type of
wound desiccation.92-
 93 Histological examination suggests
that the epithelialization rate is increased when wounds are
covered with nanofibrous PU membrane.