monkeypox is a major global public health concern, commonly referred to as mpox, is a viral zoonotic illness brought on by viruses belonging to the Orthopoxvirus family.(PubMed, 2023), so a thorough investigation that looks at how hand hygiene affects the spread of monkeypox, evaluates the preventive advantages of this practice, and offers ways to encourage It is sorely needed as a vital component of the battle against the sickness.Linking community behavior to cleanliness through researching handwashing practices can reveal social and cultural constraints that influence compliance and with this knowledge we can develop more focused and successful educational initiatives (Lancet Microbe, 2023), this study objective aim to explores how personal hygiene habits influence the spread of disease within communities, families, and healthcare settings, It also examines scientific data on the relationship between hand hygiene and the transmission of the monkeypox virus, focusing in particular on its impact among healthcare workers and similar environments (PubMed, 2023)., so It's important to understand that, whether through direct or indirect contact, good hand washing with soap and water and the use of alcohol-based sanitizers can dramatically lower the spread of monkeypox?(Journal of Infectious Diseases, 2023), so the important of the study is to help to emphasize how can hand hygiene effects the spread of mpox, the sometimes disregarded role that hand hygiene has in Preventing the Global Infectious Disease from Spreading since monkeypox spread to previously uninfected nations, it has grown to be a serious worldwide health concern, so Developing effective prevention techniques to help reduce infections requires an understanding of the relationship between hand cleanliness and minimizing the spread of this virus, and one of the easiest ways is Hand washing(Frontiers in Public Health, 2023).Endorsing National and International Health Policies, It's critical to present scientific data that governments and health organizations may utilize to develop educational initiatives and policies that highlight the need of hand cleanliness, In order to improve our readiness for upcoming pandemics connecting the Prevention of Monkeypox to Other Infectious Diseases, we need to make it abundantly evident how good hand cleanliness can help avoid a variety of illnesses.poor hand hygiene is linked to higher infection rates in this densely populated or quarantined environments, so spreading a culture of hand washing can help reduce the transmission of monkeypox through indirect contact, such as touching contaminated objects or surfaces (Lancet Microbe, 2023), also awareness programs and health initiatives that emphasize hand hygiene have been shown to lower infection rates compared to communities without these efforts,(Journal of Infectious Diseases, 2023).In addition Promotion of Public Health and Raising Awareness in the Community to improve general quality of life, when people are aware of practicing proper hygiene, which includes frequent washing, helps avoiding contagious diseases, And one of the important ways is providing Comprehensive health regulations with scientific evidence that governments and global health organizations may utilize to develop legislation and awareness campaigns that encourage hand hygiene in public and medical environments.Direct touch with an infected person's skin lesions or bodily fluids, contaminated surfaces, and even respiratory droplets can all spread the virus(Lancet Microbe, 2023).The purpose of this study is to highlight how important hand cleanliness is in preventing the transmission of monkeypox.