Lung cancer is statistically one of the most 
common diseases worldwide, and presents a serious threat to human health and life1,2.In this study, we explored the effect of curcumin on proliferation in NSCLC A549 cells and 
investigated its associated mechanism.Curcumin is a yellow 
pigment found in turmeric rhizomes, reported to 
exhibit various anti-inflammatory, anti-angiogenic, anti-proliferative, and antioxidant properties.Oxidative stress is one of the most common 
causes of cellular damage, mostly due to the 
build-up of reactive oxygen species (ROS) free 
radicals through impairments to antioxidative 
enzymes, such as superoxide dismutase (SOD).In the absence of Wnt binding (off-state), 
?-catenin is downregulated via a degradation 
complex including GSK-3, CK1, Axin, APC, and 
PP2A14,15.Results 
indicated that curcumin could inhibit NSCLC 
proliferation induced by oxidative stress-mediated upregulation of the Wnt/?-catenin pathway.Previous studies have reported that the 
Wnt/?-catenin signaling pathway is abnormally 
active in hepatic carcinoma16.In recent 
decades, lung cancer death rates have increased 
yearly in an apparent trend, particularly nonsmall-cell lung cancer (NSCLC)3
.?-catenin, which is deregulated in many cancers, is 
a multifunctional adaptor protein/transcription 
factor.Apoptosis is a 
programmed cell death process related to tumor 
malignancy, and is very important in embryonic 
development and tissue homeostasis.