Lakhasly

Online English Summarizer tool, free and accurate!

Summarize result (100%)

Some alterations in the RBCs induced by the D-gal model are also characteristic
for natural aging.
This model causes a significant decrease in RBC deformability, which
affects their rheological properties and their ability to squeeze through microvessels.
When
compared with the control, deterioration of RBC morphology in the D-gal model follows
the trend observed in natural aging of C57BL/6J mice, namely, a decrease in MCV and an
increase in MCHC.
It is worth highlighting that comparison of the dry smears of fresh RBCs
isolated from the studied groups of animals did not provide any statistically significant
changes in their RBC shape (majority with a bio-concave shape).
This stays in agreement
with our previous results, where we have evaluated the morphological alterations and
ultrastructural features among the control and natural aging groups in C57BL/6J RBCs
using not only the classical dry smear analysis, but also nano-scale AFM to finely analyze
the RBC ultrastructural features [3].
Those results clearly proved that only detailed AFM
analysis provided insight into an age-dependent decrease in RBC height and no signs of
ultrastructural deteriorations in RBC morphology were found.

The biochemical composition of RBC membranes observed in the D-gal model and
natural aging includes a decrease in the phospholipid amount, lipid unsaturation level,
and an increase in acyl chain shortening.
Even though some alterations are not statistically
significant in the D-gal model, their direction remains the same as in natural aging.
Here
we may list the changes to the secondary structure of the proteins of intact RBCs, revealed
by a decrease in the ratio of turns to α-helices, a decrease in MCH and LDL, and lack of
changes in RDW and blood plasma parameters, such as HDL, cholesterol, triglycerides,
and LDH. Altogether, these suggest that the D-gal model mimics both the mechanical and
functional properties of the RBCs of naturally aging mice.

It was previously reported that alterations in the secondary structures of proteins
in intact RBCs may be regarded as biomarkers of aging or specific diseases.
Progressive


Original text

Some alterations in the RBCs induced by the D-gal model are also characteristic
for natural aging. This model causes a significant decrease in RBC deformability, which
affects their rheological properties and their ability to squeeze through microvessels. When
compared with the control, deterioration of RBC morphology in the D-gal model follows
the trend observed in natural aging of C57BL/6J mice, namely, a decrease in MCV and an
increase in MCHC. It is worth highlighting that comparison of the dry smears of fresh RBCs
isolated from the studied groups of animals did not provide any statistically significant
changes in their RBC shape (majority with a bio-concave shape). This stays in agreement
with our previous results, where we have evaluated the morphological alterations and
ultrastructural features among the control and natural aging groups in C57BL/6J RBCs
using not only the classical dry smear analysis, but also nano-scale AFM to finely analyze
the RBC ultrastructural features [3]. Those results clearly proved that only detailed AFM
analysis provided insight into an age-dependent decrease in RBC height and no signs of
ultrastructural deteriorations in RBC morphology were found.
The biochemical composition of RBC membranes observed in the D-gal model and
natural aging includes a decrease in the phospholipid amount, lipid unsaturation level,
and an increase in acyl chain shortening. Even though some alterations are not statistically
significant in the D-gal model, their direction remains the same as in natural aging. Here
we may list the changes to the secondary structure of the proteins of intact RBCs, revealed
by a decrease in the ratio of turns to α-helices, a decrease in MCH and LDL, and lack of
changes in RDW and blood plasma parameters, such as HDL, cholesterol, triglycerides,
and LDH. Altogether, these suggest that the D-gal model mimics both the mechanical and
functional properties of the RBCs of naturally aging mice.
It was previously reported that alterations in the secondary structures of proteins
in intact RBCs may be regarded as biomarkers of aging or specific diseases. Progressive


Summarize English and Arabic text online

Summarize text automatically

Summarize English and Arabic text using the statistical algorithm and sorting sentences based on its importance

Download Summary

You can download the summary result with one of any available formats such as PDF,DOCX and TXT

Permanent URL

ٌYou can share the summary link easily, we keep the summary on the website for future reference,except for private summaries.

Other Features

We are working on adding new features to make summarization more easy and accurate


Latest summaries

يمكن أن يتم است...

يمكن أن يتم استهداف هذه البيانات من قبل المتسللين للوصول إلى البيانات الحساسة المدفوعة بفرص الربح ال...

في الواقع، توجد...

في الواقع، توجد مثل هذه الدورات في بعض الأحيان. في بعض الحالات كان من الممكن إثبات مثل هذه التقلبات ...

تعد مصلحة المست...

تعد مصلحة المستخدمين المفتشية اإلقليمية للتجارة من الجهات الحكومية التي تلعب دو ًرا حيوًيا في تنظيم ...

الشعر وتطوّره 1...

الشعر وتطوّره 1 استمرار التقليد كان الشعر يجرى فى مصر فى أثناء النصف الأول من القرن التاسع عشر على ا...

ظلت حركة الاستش...

ظلت حركة الاستشراق على امتداد تاريخها الطويل ترتقي مع كل مرحلة من مراحلها واتخذت خلالها العديد من ال...

عرفه العيني: "أ...

عرفه العيني: "أن يطلب من الصانع أن يصنع له شيئاً بثمن معلوم". لأنه باع ما ليس عنده على غير وجه السلم...

أهمية التدريب :...

أهمية التدريب : تحسين الأداء الحاضر، والتأهيل المسؤوليات اكبر في المستقبل، كما انه هدم بالنسبة للأف...

المقالة نوع من ...

المقالة نوع من الأدب، هي قطعة إنشائية، ذات طول معتدل تُكتب نثراً، وتهتمُّ بالمظاهر الخارجية للموضوع ...

Hospital inform...

Hospital information systems (HIS) have been used for decades around the world. Many hospitals in Sa...

اختلفت ردود الأ...

اختلفت ردود الأفعال في العالم العربي والعالم الغربي، ففي العالم الغربي لم يعد أحد يريد أن يكتب عن ال...

الحرب الفيتنامي...

الحرب الفيتنامية موقف الولايات المتحدة الغارات الجوية على فيتنام الشمالية في فبراير عام ١٩٦٥ ، ...

تعتمد قوة عروض ...

تعتمد قوة عروض الوسائط المتعددة على تكامل العناصر التي تشملها فلا يمكن ان يدخل عنصر من عناصر الوسائط...