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Bioreactors provide controlled delivery of nutrients and biomi- metic stimuli in order to influence cell growth, differentiation, and tissue formation.In this review, we will provide a critical overview of biomedical applications of bioreactors and discuss current trends and recent advances that promote the application of bioreactor technologies for single-cell manufacture, production of engineered tissue grafts, and drug screening.These advantages include (i) improved standardization and reproducibility, (ii) scale-up to larger, clinically relevant tissue grafts or cell expansion scales, (iii) superior functionality compared with 3D grafts cultured in tissue culture flasks, and (iv) improved systems for testing cell responses to a range of experimental parameters.


Original text

Bioreactors provide controlled delivery of nutrients and biomi- metic stimuli in order to influence cell growth, differentiation, and tissue formation. They have been extensively used to promote the expansion of red blood cells, chimeric antigen receptor (CAR) T cells, induced pluripotent stem cells, and mesenchymal stem cells. Additionally, the ability to control the spatiotemporal delivery of the biological, biochemical, and biophysical signals that regulate tissue development confers a number of advantages for engineering 3D tissues relative to standard cell culture techniques by providing well-defined conditions to regulate cell behaviors. These advantages include (i) improved standardization and reproducibility, (ii) scale-up to larger, clinically relevant tissue grafts or cell expansion scales, (iii) superior functionality compared with 3D grafts cultured in tissue culture flasks, and (iv) improved systems for testing cell responses to a range of experimental parameters. As the field of regenerative medicine has matured, the number of applications has increased and the roles that bioreactors play in enabling the commercialization and clinical translation of stem cell-based technologies have become more defined. In this review, we will provide a critical overview of biomedical applications of bioreactors and discuss current trends and recent advances that promote the application of bioreactor technologies for single-cell manufacture, production of engineered tissue grafts, and drug screening.

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