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In humans exposure to lead can result in a wide range of biological effects depending on the level and duration of exposure.For the majority of people in the UK, however, dietary lead exposure is well below the provisional tolerable weekly intake recommended by the UN Food and Agriculture Organisation and the World Health Organisation.High levels of exposure may result in toxic biochemical effects in humans which in turn cause problems in the synthesis of haemoglobin, effects on the kidneys, gastrointestinal tract, joints and reproductive system, and acute or chronic damage to the nervous system.Various effects occur over a broad range of doses, with the developing foetus and infant being more sensitive than the adult.At intermediate concentrations, however, there is persuasive evidence that lead can have small, subtle, subclinical effects, particularly on neuropsychological developments in children.
In humans exposure to lead can result in a wide range of biological effects depending on the level and duration of exposure. Various effects occur over a broad range of doses, with the developing foetus and infant being more sensitive than the adult. High levels of exposure may result in toxic biochemical effects in humans which in turn cause problems in the synthesis of haemoglobin, effects on the kidneys, gastrointestinal tract, joints and reproductive system, and acute or chronic damage to the nervous system.
Lead poisoning, which is so severe as to cause evident illness, is now very rare indeed. At intermediate concentrations, however, there is persuasive evidence that lead can have small, subtle, subclinical effects, particularly on neuropsychological developments in children. Some studies suggest that there may be a loss of up to 2 IQ points for a rise in blood leadlevels from 10 to 20µg/dl in young children.
Average daily lead intake for adults in the UK is estimated at 1.6µg from air, 20µg from drinking water and 28µg from food. Although most people receive the bulk of their lead intake from food, in specific populations other sources may be more important, such as water in areas with lead piping and plumbosolvent water, air near point of source emissions, soil, dust, paint flakes in old houses or contaminated land. Lead in the air contributes to lead levels in food through deposition of dust and rain containing the metal, on crops and the soil. For the majority of people in the UK, however, dietary lead exposure is well below the provisional tolerable weekly intake recommended by the UN Food and Agriculture Organisation and the World Health Organisation.
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