لخّصلي

1.Mango

Mango is classified a level I causation, which is highly probable of having an interaction if consumed in large amounts with warfarin The exact interaction mechanism is unknown, but may be related to the vitamin A content(inhibit CYP2C19 enzymes).Foods Causing Inhibition:

High Vitamin-K Containing Foods

High Vitamin-K containing foods are classified a level 1 causation, which are highly probable of causing a lowered INR or clotting event when consumed with warfarin.Grapefruit juice

Grapefruit juice is a well-known inhibitor of cytochrome P450 (CYP) liver enzymes, primarily CYP3A4, CYP1A2 and CYP2A6.2.

Mango

Mango is classified a level I causation, which is highly probable of having an interaction if consumed in large amounts with warfarin The exact interaction mechanism is unknown, but may be related to the vitamin A content(inhibit CYP2C19 enzymes).

Grapefruit juice

Grapefruit juice is a well-known inhibitor of cytochrome P450 (CYP) liver enzymes, primarily CYP3A4, CYP1A2 and CYP2A6. The result of consuming grapefruit during warfarin therapy will probably potentiate or enhance the anticoagulant effects of warfarin in patients.

Foods Causing Inhibition:

High Vitamin-K Containing Foods

High Vitamin-K containing foods are classified a level 1 causation, which are highly probable of causing a lowered INR or clotting event when consumed with warfarin. Vitamin K is a fat-soluble vitamin and serves as a cofactor for the production of clotting factors. The primary sources of vitamin K-containing foods are dark green vegetables. Patients who take warfarin should aim to eat a relatively similar amount of vitamin K each week. The highest amount of vitamin K is found in green and leafy vegetables such as broccoli, lettuce, and spinach. It is not necessary to avoid these foods; however, it is important to try to keep the amount of vitamin K you eat consistent.