لخّصلي

Endometrial hyperplasia (EH) is a condition characterized by excessive growth of the uterine glands in the endometrium.It inhibits the production of pro-inflammatory mediators, alters protein levels involved in apoptosis, inhibits cell proliferation, and exhibits antioxidant activity.Oxidative stress and inflammation play a role in the development of EH. Apoptosis, the process of programmed cell death, helps maintain cellular balance in the endometrium, and treatment often involves progestins to enhance apoptosis.

Endometrial hyperplasia (EH) is a condition characterized by excessive growth of the uterine glands in the endometrium. EH can occur in response to hormonal imbalances and is classified as either with or without atypia. EH with atypia is considered a precancerous lesion, increasing the risk of developing endometrial carcinoma if left untreated. Oxidative stress and inflammation play a role in the development of EH. Apoptosis, the process of programmed cell death, helps maintain cellular balance in the endometrium, and treatment often involves progestins to enhance apoptosis. Hysterectomy is an option for treatment but comes with significant consequences. Cordycepin, a substance extracted from Cordyceps militaris, has anti-inflammatory, anticancer, and antioxidant properties. It inhibits the production of pro-inflammatory mediators, alters protein levels involved in apoptosis, inhibits cell proliferation, and exhibits antioxidant activity. The study aims to investigate the protective effects of cordycepin against estrogen-induced EH in rats.