لخّصلي

This study investigated the prevalence and patient awareness of the risk of CKD progression in individuals with OSA. 1295 adults referred to Canadian sleep centers for suspected OSA underwent testing and provided samples for eGFR and ACR measurements. CKD progression risk was assessed based on a heat map using these parameters.

The study found that 13.6% of individuals with no/mild OSA, 28.9% of those with moderate OSA, and 30.9% with severe OSA had a moderate-to-very high risk of CKD progression (p < .001). After adjusting for CKD risk factors, the odds of moderate-to-very high risk were significantly higher for moderate and severe OSA compared to no/mild OSA. Notably, 73% of patients at increased risk were unaware of their abnormal kidney function.

The conclusion highlights that patients with moderate and severe OSA have an increased risk of CKD progression, independent of other risk factors, and most are unaware of this elevated risk.

Study Objectives
Chronic kidney disease (CKD) is a global health concern and a major risk factor for cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA) may exacerbate this risk by contributing to the development of CKD. This study investigated the prevalence and patient awareness of the risk of CKD progression in individuals with OSA.
Methods
Adults referred to five Canadian academic sleep centers for suspected OSA completed a questionnaire, a home sleep apnea test or in-lab polysomnography and provided blood and urine samples for measurement of estimated glomerular filtration rate (eGFR) and the albumin:creatinine ratio (ACR), respectively. The risk of CKD progression was estimated from a heat map incorporating both eGFR and ACR.
Results
1295 adults (42% female, 54 ± 13 years) were categorized based on the oxygen desaturation index (4% desaturation): 30 (severe OSA, n = 421). After stratification, 13.6% of the no/mild OSA group, 28.9% of the moderate OSA group, and 30.9% of the severe OSA group had a moderate-to-very high risk of CKD progression (p < .001), which was defined as an eGFR