لخّصلي

In conclusion, numerous preclinical studies have demonstrated beneficial effects of curcumin on cognition in AD and non-pathological aging.Preliminary evidence from human studies supports preclinical findings that curcumin may stabilizes/prevents cognitive decline rather than improves it in healthy population.Since, curcumin is an interesting compound with potential capability of preventing cognitive decline, it is crucial to find ways to bridge this translational gap.Thus, as current treatments for cognitive impairments re- main insufficient and are accompanied by severe side-effects, curcumin may be a promising alternative.

In conclusion, numerous preclinical studies have demonstrated beneficial effects of curcumin on cognition in AD and non-pathological aging. However, a limited number of human studies was identified, and these results are less consistent than results of preclinical work. Preliminary evidence from human studies supports preclinical findings that curcumin may stabilizes/prevents cognitive decline rather than improves it in healthy population. Since, curcumin is an interesting compound with potential capability of preventing cognitive decline, it is crucial to find ways to bridge this translational gap. An important advantage of curcumin is that constitutes a natural, widely available compound. Thus, it does not involve a great economic burden for the patients that might benefit from its use. Additionally, even though studies have reported mild side effects in the elderly patients at a high dose, curcumin demonstrates a safer profile compared to the current compounds. Thus, as current treatments for cognitive impairments re- main insufficient and are accompanied by severe side-effects, curcumin may be a promising alternative. However, further research to improve curcumin’s bioavailability is crucial and more human trials examining curcumin’s cognitive enhancing effect are necessary.