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Type II hypersensitivity, also known as cytotoxic hypersensitivity or antibody-mediated hypersensitivity, is a category of immune responses characterized by the inappropriate activation of the immune system against specific target cells or tissues.Examples of type II hypersensitivity reactions include autoimmune hemolytic anemia, Rh incompatibility reactions, and certain drug-induced immune responses.These mechanisms include complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), and phagocytosis by macrophages.
Type II hypersensitivity, also known as cytotoxic hypersensitivity or antibody-mediated hypersensitivity, is a category of immune responses characterized by the inappropriate activation of the immune system against specific target cells or tissues. In type II hypersensitivity, the immune system produces antibodies, typically IgG or IgM, that recognize and bind to antigens present on the surface of host cells or tissues.
The binding of antibodies to these antigens triggers various immune mechanisms that can lead to tissue damage or dysfunction. These mechanisms include complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), and phagocytosis by macrophages.
The consequences of type II hypersensitivity can vary depending on the target cells or tissues involved. Examples of type II hypersensitivity reactions include autoimmune hemolytic anemia, Rh incompatibility reactions, and certain drug-induced immune responses.
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