Lakhasly

Oral antihistamines (H1 receptor antagonists.Examples of topical intranasal antihistamines include olopatadine and azelastine .Combinations of antihistamines with decongestants .are effective when congestion is a feature of rhinitis, or when patients have no response or incomplete control of symptoms with intranasal corticosteroids.First-generation antihistamines, such as diphenhydramine and chlorpheniramine, are usually not preferred due to adverse effects, such as sedation, performance impairment, and other anticholinergic effects.The second-generation antihistamines (for example, fexofenadine, loratadine, desloratadine, cetirizine) are generally better tolerated.

Oral antihistamines (H1 receptor antagonists. have a fast onset of action and are useful for the
management of symptoms of allergic rhinitis caused by histamine release, such as sneezing, watery rhinorrhea, and itchy eyes/nose. However, they are more effective for prevention of symptoms in mild or intermittent disease, rather than treatment once symptoms have begun. First-generation antihistamines, such as diphenhydramine and chlorpheniramine, are usually not preferred due to adverse effects, such as sedation, performance impairment, and other anticholinergic effects. The second-generation antihistamines (for example, fexofenadine, loratadine, desloratadine, cetirizine) are generally better tolerated. Ophthalmic and nasal antihistamine delivery devices are available for targeted, topical tissue delivery. Examples of topical intranasal antihistamines include olopatadine and azelastine . Intranasal antihistamines provide increased delivery of the drug with fewer adverse effects. Combinations of antihistamines with decongestants .are effective when congestion is a feature of rhinitis, or when patients have no response or incomplete control of symptoms with intranasal corticosteroids.