Online English Summarizer tool, free and accurate!
Incretin Mimetics
Incretin effect is the difference in insulin secretory response from an oral glucose load in comparison to glucose administered intravenously. The incretin effect is responsible for 50–70% of total insulin secretion after oral glucose intake (35). The two naturally occurring incretin hormones that play important roles in the maintenance of glycemic control: glucose-dependent insulinotropic polypeptide (GIP, or incretin) and glucagon-like peptide (GLP-1); these peptides have a short half-life, as these are rapidly hydrolyzed by DPP-4 inhibitors within 1½ min. In patients with T2DM, the incretin effect is reduced or absent. In particular, the insulinotropic action of GIP is lost in patients with T2DM. Incretins decrease gastric emptying and causes weight loss. Because of impact on weight loss, these medications may find increasing use in diabesity.
Targeting the incretin system has become an important therapeutic approach for treating T2DM. These two drug classes include GLP-1 receptor agonists and DPP-4 inhibitors. Clinical data have revealed that these therapies improve glycemic control while reducing body weight (specifically, GLP-1 receptor agonists) and systolic blood pressure in patients with T2DM (36). Furthermore, hypoglycemia is low (except when used in combination with a sulfonylurea) because of their glucose-dependent mechanism of action.
Incretin Mimetics
Incretin effect is the difference in insulin secretory response from an oral glucose load in comparison to glucose administered intravenously. The incretin effect is responsible for 50–70% of total insulin secretion after oral glucose intake (35). The two naturally occurring incretin hormones that play important roles in the maintenance of glycemic control: glucose-dependent insulinotropic polypeptide (GIP, or incretin) and glucagon-like peptide (GLP-1); these peptides have a short half-life, as these are rapidly hydrolyzed by DPP-4 inhibitors within 1½ min. In patients with T2DM, the incretin effect is reduced or absent. In particular, the insulinotropic action of GIP is lost in patients with T2DM. Incretins decrease gastric emptying and causes weight loss. Because of impact on weight loss, these medications may find increasing use in diabesity.
Targeting the incretin system has become an important therapeutic approach for treating T2DM. These two drug classes include GLP-1 receptor agonists and DPP-4 inhibitors. Clinical data have revealed that these therapies improve glycemic control while reducing body weight (specifically, GLP-1 receptor agonists) and systolic blood pressure in patients with T2DM (36). Furthermore, hypoglycemia is low (except when used in combination with a sulfonylurea) because of their glucose-dependent mechanism of action.
Summarize English and Arabic text using the statistical algorithm and sorting sentences based on its importance
You can download the summary result with one of any available formats such as PDF,DOCX and TXT
ٌYou can share the summary link easily, we keep the summary on the website for future reference,except for private summaries.
We are working on adding new features to make summarization more easy and accurate
عند إضافة نوع خاطئ من المواد المضادة لبكتيريا معينة ترفض هذه البكتيريا التعامل مع هذه المادة فبالتا...
ويستثمرون بشكل عام أو يديرون أصول العميل وفقًا لاحتياجات العميل ومتطلباته ورغبتهم في المخاطرة،ولديهم...
5- تأثير تغير السعة على التيار فكلما انخفضت قيمة السعة زادت القيمة الحالية والقوة التفاعلية وكذلك با...
نشأ احمد شوقى في عائلة ثرية من جذور تركية وعربية وشركسية ويونانية مختلطة ، كانت عائلته بارزة ومتصلة ...
The reason for adopting this new technology in many residential areas is that photovoltaic systems m...
We offer different package for our services the price determine on the kind of service customer ask ...
عد سرعة التغبير والتطور سمة العصر الذي نعيش فيه ، ويشهد عصرنا الحالي تطوراً هائلاً في المعلومات وتغي...
organizational level whereas informal communication occurs naturally. Documentary evidence is always...
Computing and learning generalized patterns of behavior that address multiple related problems is a ...
Title:طرح المشكلة يقول "أرسطو" :"الإنسان كائن عاقل، وهذا معناه أنه يستخدم عقله لممارسة فن,Content:طر...
مهاجرون ... إلى لا مكان مخدوعون أناس بسطاء دفعوا عدة آلاف من الدولارات لقاء وعد غامض بالهجرة، ولكن ا...
وقبل أن يحدث هذا الاتصال كانت منابع النيل مشتتة جدا ، . كذلك فان من المستحيل ان يعبر أى نهر جبال تب...