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Hypotension, condition in which the blood pressure is abnormally low, either because of reduced blood volume or because of increased blood-vessel capacity.Norepinephrine increases blood pressure by inducing peripheral arterial and venous vasoconstriction.So, if there is any hepatic impairment, the dose should be adjusted accordingly.Metabolism The drug is metabolized by the liver.
Hypotension, condition in which the blood pressure is abnormally low, either because of reduced blood volume or because of increased blood-vessel capacity. Though not in itself an indication of ill health, it often accompanies disease
(Orvaten), droxidopa
Adverse Effects
Paresthesia
Piloerection
Pruritus
Supine hypertension
Urinary retention or urgency
Mechanism of Action
Alpha-1 selective adrenergic agonist; increases peripheral vascular resistance; arteriolar and venous tone increases and results in a rise in sitting, standing, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension
Absorption
Bioavailability: 93%
Onset: 45-90 min (initial effect); 60 min (max effect)
Northera), fludrocortisone
Adverse Effesevere dizziness or light-headed feeling;
confusion, fever
pain or burning when you urinatcts
Mechanism of Action
Northera is believed to exert its pharmacological effects through norepinephrine and not through the parent molecule or other metabolites. Norepinephrine increases blood pressure by inducing peripheral arterial and venous vasoconstriction.
Metabolism
The drug is metabolized by the liver. So, if there is any hepatic impairment, the dose should be adjusted accordingly.
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