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Ammonia is
considered the major etiologic factor in the development of
encephalopathy.
Ammonia is
considered the major etiologic factor in the development of
encephalopathy. Ammonia enters the brain and excites peripheral
benzodiazepine-type receptors on astrocyte cells, increasing neurosteroid
synthesis, and stimulating gamma-aminobutyric acid (GABA)
neurotransmission. GABA causes depression of the central nervous system
that inhibits neurotransmission and synaptic regulation , producing sleep and behavior patterns associated
with hepatic encephalopathy
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