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There are also questions about whether
it matters that apoptotic activity in the fetal liver is raised
transiently, and there is some difficulty in explaining the
mechanisms of damage (whether due to thermal or nonthermal effects).However, recent research
has advocated Doppler measurement of the cardiac and
infracardiac regions of the 11 to 13 + 6-week fetus5,6.There are, however, two other recent
animal studies which have demonstrated a relationship
between length of exposure to Doppler ultrasound and
potentially irreversible biological effects3,4.
There are also questions about whether
it matters that apoptotic activity in the fetal liver is raised
transiently, and there is some difficulty in explaining the
mechanisms of damage (whether due to thermal or nonthermal effects). There are, however, two other recent
animal studies which have demonstrated a relationship
between length of exposure to Doppler ultrasound and
potentially irreversible biological effects3,4.
In many countries today, more than 70% of all
pregnancies undergo nuchal translucency screening at 11
to 13 + 6 weeks. From an ultrasound safety perspective,
this is not problematic as long as it is performed with
low-intensity B-mode ultrasound by properly trained
sonographers or sonologists. However, recent research
has advocated Doppler measurement of the cardiac and
infracardiac regions of the 11 to 13 + 6-week fetus5,6.
Since Doppler usually generates higher intensity outputs
than does B-mode ultrasound, the question of safety must
be considered.
Also in this issue of the Journal, there is a new ISUOG
(International Society of Ultrasound in Obstetrics and
Gynecology) statement on the use of Doppler ultrasound
at 11 to 13 + 6 weeks7, and this Opinion discusses some
of the issues raised
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