Lakhasly

Formaldehyde is commonly found in various sources such as cigarette smoke, emissions from automobiles, fuel oil, natural gas, exhaust from vehicles powered by fossil fuels, furniture, and the fumes emitted by chipboard paint.Any disorders of its expression would induce cancer diseases The reason is that the P53 protein functions as a transcription factor, which is normally regulated and controls the expression of genes in cells and prevents cancer formation (14).Disinfectants and sterilizers are commonly employed by educational institutions, higher education establishments, as well as biological, forensic, and pathological laboratories to safeguard tissues, surgical specimens, organs, and viscera (1,2).It was reported that broilers at eight weeks old revealed a reduction in feed intake and body mass, occurrence of local necrosis, as well as crop and intestinal hemorrhage after the administration of formalin in feed at different concentrations (12, 13).The presence of formic acid in the bloodstream leads to the development of a significant metabolic acidosis, while also impairing liver function through the inhibition of cholinesterase, succinate oxidation, and anaerobic glycolysis (3,4).The P53 protein, also known as the protein TP53, is a tumor suppressor protein encoded by the TP53 gene in humans So, this protein plays a crucial role in regulating cell growth and preventing the formation of cancerous tumors.

Formaldehyde is commonly found in various sources such as cigarette smoke, emissions from automobiles, fuel oil, natural gas, exhaust from vehicles powered by fossil fuels, furniture, and the fumes emitted by chipboard paint. Disinfectants and sterilizers are commonly employed by educational institutions, higher education establishments, as well as biological, forensic, and pathological laboratories to safeguard tissues, surgical specimens, organs, and viscera (1,2).
The inhalation of formalin has been observed to impact plasma proteins, leading to their conversion into formic acid by the liver and red blood cells. This process has been associated with the development of severe toxicity and increased mortality rates. The presence of formic acid in the bloodstream leads to the development of a significant metabolic acidosis, while also impairing liver function through the inhibition of cholinesterase, succinate oxidation, and anaerobic glycolysis (3,4).
United States allows for a maximum formalin content of 2.5 kilograms per ton in poultry feed (11). It was reported that broilers at eight weeks old revealed a reduction in feed intake and body mass, occurrence of local necrosis, as well as crop and intestinal hemorrhage after the administration of formalin in feed at different concentrations (12, 13).
The P53 protein, also known as the protein TP53, is a tumor suppressor protein encoded by the TP53 gene in humans So, this protein plays a crucial role in regulating cell growth and preventing the formation of cancerous tumors. Any disorders of its expression would induce cancer diseases The reason is that the P53 protein functions as a transcription factor, which is normally regulated and controls the expression of genes in cells and prevents cancer formation (14).
P53 would induce these cellular responses to help prevent the proliferation of damaged or abnormal cells, which can lead to cancer formation (15). Importantly, mutations in the TP53 gene can lead to the loss of TP53 function, increasing the risk factor of cancer development. Previous research on formalin and P53 pushed us to study the effect of formalin gas on the liver and kidney of quail birds in relation to TP53 expression and activity. Accordingly, it might be selected as a biomarker and indicator for risk factors of formalin gas in humans and animals, particularly regular exposure to formalin gas and the impaction of formalin gas on liver and kidney function at different times. Therefore, this study aimed to study the functions of the liver and kidneys in relation to TP53 gene expression in the digestive and urinary systems of quails after exposure to 5% of the formalin gas at different periods and days.