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1 Drug stability is often reduced in solution by solvolysis, hydrolysis or oxidation.In order to measure an accurate dose (this will have cost implications).The stability of the active ingredient needs to be taken into consideration when formulating a solution
For this reason, it is common for solutions to attract a shorter expiry date than equivalent solid dosage forms.2.The solubility of a drug needs to be taken into consideration when preparing a solution to ensure that the final volume produced is not excessive.SAC
Although liquid dosage forms may be ideal for small children who are unable to swallow solid dosage forms, many drugs taste unpleasant when formulated into a solution.Technical accuracy is needed to measure the dose on administration.3.????4..???...
1 Drug stability is often reduced in solution by solvolysis, hydrolysis or oxidation.
The stability of the active ingredient needs to be taken into consideration when formulating a solution
For this reason, it is common for solutions to attract a shorter expiry date than equivalent solid dosage forms.2. It is difficult to mask unpleasant tastes. SAC
Although liquid dosage forms may be ideal for small children who are unable to swallow solid dosage forms, many drugs taste unpleasant when formulated into a solution.
. Although the dose can be titrated without the need to produce additional preparations, patient accuracy in measuring a dose is required. دید
.
This is important when the volume of liquid to be
administered is very small, where small changes in the volume administered may result in large increases or decreases in dose5. Some drugs are poorly soluble.
The solubility of a drug needs to be taken into consideration when preparing a solution to ensure that the final volume produced is not excessive.
In some cases it is necessary to alter the vehicle or drug form (for example the free alkaloid or its salt) in order to be able to formulate preparation.6. A measuring device is needed for administration.
. In order to measure an accurate dose (this will have cost implications).
. The patient will need counseling on the use of the measuring device.
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