Lakhasly

Rectal gel (Ritschel WA, Ritschel GB, et al. (1988) and suppositories has shown accurate results.But due to absence of absorption enhancers, bioavailability of therapeutic peptides and proteins through rectal administration is less than achieved by intramuscular, intravenous or subcutaneous route of administration so absorption enhancers are used and it was found that sodium salicylate and 5methoxysalicylate is proved successful in enhancing the rectal absorption of insulin.(Yun M, Choi H, Jung J, Kim C. (1999).

Rectal gel (Ritschel WA, Ritschel GB, et al. (1988) and suppositories has shown accurate results. Still this route is not commerically feasible. Rectal insulin delivery give several advantages above some of other route of delivery. But due to absence of absorption enhancers, bioavailability of therapeutic peptides and proteins through rectal administration is less than achieved by intramuscular, intravenous or subcutaneous route of administration so absorption enhancers are used and it was found that sodium salicylate and 5methoxysalicylate is proved successful in enhancing the rectal absorption of insulin. (Yamasaki Y, Shichiri M, et al.(1981) Insulin suppositories manage postprandial glycaemia in more physiological way than standard insulin therapy because considerable amounts of insulin absorbed from the rectum enter straight into portal vein. In a study thermoreversible insulin liquid suppository was developed, that was suitable to go through a phase transition to bioadhesive gels at body temperature and improve bioavailability of insulin. (Yun M, Choi H, Jung J, Kim C. (1999).