لخّصلي

They also produce capped genomic RNAs and subgenomic RNAs encoding the structural protein and have a polyA tail [van der Heijden and Bol, 2002].

HEV viral proteins

HEV belongs to the alphavirus-like supergroup III of RNA ss + viruses, whose members encode a type 1 helicase (Hel), a type 1 methyltransferase domain (MT), and a type 3 RdRp domain. They also produce capped genomic RNAs and subgenomic RNAs encoding the structural protein and have a polyA tail [van der Heijden and Bol, 2002]. Animal viruses from this supergroup include members of the genera Alphavirus and Rubivirus and the subfamily Orthohepevirinae of the families Togaviridae, Matonaviridae, and Hepeviridae, respectively. Although HEV can circulate as a "quasi-enveloped" particle, it lacks surface glycoproteins, thereby differing from enveloped animal alpha-like viruses [van der Heijden and Bol, 2002; Yin et al., 2016]. Furthermore, members of these viral families have a conserved X domain, whose function remains unknown [Koonin and Dolja, 1993]. Interestingly, alphaviruses have a genome organization similar to the one seen in plant viruses belonging to the genera Tobamovirus, Tobravirus, Hordeivirus, and Furovirus. However, the structural proteins have at least three different origins, resulting in viruses with very divergent structures [Strauss and Strauss