لخّصلي

Swyer syndrome can be inherited in a X-linked, Y-linked, autosomal dominant, or autosomal recessive manner, depending on the underlying mutation that results in the complete, or pure, gonadal dysgenesis.Meanwhile, SRY gene mutations follow a Y-linked mode of inheritance, which means that the genetic mutation is located on a Y-chromosome and therefore, is exclusively inherited from the father.For instance, NR5A1 and WNT4 mutations are inherited in an autosomal dominant manner, which means that only one copy of the mutation needs to be inherited from either parent in order for the syndrome to be expressed.

Swyer syndrome can be inherited in a X-linked, Y-linked, autosomal dominant, or autosomal recessive manner, depending on the underlying mutation that results in the complete, or pure, gonadal dysgenesis.

Cases of Swyer syndrome due to mutation of the NROB1 gene may be inherited in an X-linked pattern, which means that the genetic mutation is located on an X-chromosome, and is most often inherited from the mother. Meanwhile, SRY gene mutations follow a Y-linked mode of inheritance, which means that the genetic mutation is located on a Y-chromosome and therefore, is exclusively inherited from the father.

There are also several genetic mutations on autosomal chromosomes that can result in Swyer syndrome, and can therefore be inherited in an autosomal dominant or autosomal recessive manner. For instance, NR5A1 and WNT4 mutations are inherited in an autosomal dominant manner, which means that only one copy of the mutation needs to be inherited from either parent in order for the syndrome to be expressed. On the other hand, autosomal recessive mutations require two mutated copies of the affected gene, one from each parent, in order for Swyer syndrome to develop. Mutations of the DHH gene are inherited in an autosomal recessive manner.