Lakhasly

Most of the drug cargo released within 1 min from GCL/DOX

upon NIR laser irradiation .Furthermore, heat produced by NIR laser irradiation could increase membrane fluidity, and cellular uptake may also be promoted.Direct heat conduction from the gold mostructures to the liposomal membranes likely increased membrane fluidity, leading to efficient burst release of DOX.Although in vivo investigations are required, rapid drug release from GCL/DOX using NIR laser irradiation as a trigger is advantageous.Monotherapy using free DOX solution alone or photothermal therapy using GCL alone was moderately cytotoxic, while a synergistic effect was observed by combining the run.La reported that the transition temperature of DPPC is around 41.7 and the initial temperature of the phase transition is

38.7, thus explaining the leakage of DOX from Lipo/DOX.The clinically applicable temperatures for hyperthermis range from 43 47 because apoptosis is induced in cancer cells above 43 and necrosis is induced above 49.GCL/DOX .combined with NIR laser irradiation showed a remarkable cytotoxic effect .

Most of the drug cargo released within 1 min from GCL/DOX

upon NIR laser irradiation . A temperature increase of the GCL samples beyond 42, the transition temperature of DPPC, was observed under several experimental conditions . We speculate that the gold nanostructures absorbed NIR laser lights and converted it into heat. Direct heat conduction from the gold mostructures to the liposomal membranes likely increased membrane fluidity, leading to efficient burst release of DOX. Although in vivo investigations are required, rapid drug release from GCL/DOX using NIR laser irradiation as a trigger is advantageous. The clinically applicable temperatures for hyperthermis range from 43 47 because apoptosis is induced in cancer cells above 43 and necrosis is induced above 49. Large amounts of GCL. are not required and the use of a high concentration of GCL induced cytotoxicity . We conclude that experimental conditions were suitable because the observed temperatures were clinically appli- cable. We also observed that a moderate amount of DOX was released from Lipo/DOX (5 min,